A comprehensive understanding of the interrelationships among various DNA dodecahedral topological configurations holds immense theoretical significance for guiding experimental synthesis and practical applications. In this study, we investigate the topological isomers of DNA dodecahedral links. We defined DNA dodecahedral links with a consistent component number and genus as topological isomers. Two distinct strategies were employed to identify potential topological isomers. The HOMFLY-polynomial has been validated as a potent tool for distinguishing the topological isomers of DNA dodecahedral links. Our research not only provides valuable insights into the comprehensive understanding of DNA nanostructures but also offers clues for scientists to screen and synthesize unexplored DNA nanostructures.